Murine tumor necrosis factor alpha is transported from blood to brain in the mouse
EG Gutierrez, WA Banks, AJ Kastin - Journal of neuroimmunology, 1993 - Elsevier
The cytokines are important components of the brain-immune axis. Recent work has shown
thet [125 I] IL-1α and [125 I] IL-1β are transported from the blood into the brain by a saturable
system. Here we show that murine tumor necrosis factor alpha (mTNFα) _ labeled with 125 I
(I-mTNFα) crosses the blood-brain barrier (BBB) after iv injection by a transport system
different from that for the interleukins. Self inhibition with mTNFα showed that this transport
system was saturable, and lack of inhibition by IL-1β, IL-6, or MIP-1α showed selectivity of …
thet [125 I] IL-1α and [125 I] IL-1β are transported from the blood into the brain by a saturable
system. Here we show that murine tumor necrosis factor alpha (mTNFα) _ labeled with 125 I
(I-mTNFα) crosses the blood-brain barrier (BBB) after iv injection by a transport system
different from that for the interleukins. Self inhibition with mTNFα showed that this transport
system was saturable, and lack of inhibition by IL-1β, IL-6, or MIP-1α showed selectivity of …
