Skeletal muscle mitochondrial dysfunction is present in patients with CKD before initiation of maintenance hemodialysis
Results We found a prolonged phosphocreatine recovery constant in patients on
maintenance hemodialysis (53.3 [43.4–70.1] seconds, median [interquartile range]) and
patients with CKD not on maintenance hemodialysis (41.5 [35.4–49.1] seconds) compared
with controls (38.9 [32.5–46.0] seconds; P= 0.001 among groups). Mitochondrial dysfunction
was associated with poor physical performance (r= 0.62; P= 0.001), greater intermuscular
adipose tissue (r= 0.44; P= 0.001), and increased markers of inflammation and oxidative …
maintenance hemodialysis (53.3 [43.4–70.1] seconds, median [interquartile range]) and
patients with CKD not on maintenance hemodialysis (41.5 [35.4–49.1] seconds) compared
with controls (38.9 [32.5–46.0] seconds; P= 0.001 among groups). Mitochondrial dysfunction
was associated with poor physical performance (r= 0.62; P= 0.001), greater intermuscular
adipose tissue (r= 0.44; P= 0.001), and increased markers of inflammation and oxidative …
